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LIVE EVENT Q&A: Dr. Andrew Huberman at Meridian Hall in Toronto

Episode 2023-11-152023-11-15English
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Contents3 chapters§01Transcript — part 1§02Transcript — part 2§03Transcript — part 3

§01Transcript — part 1

00:00Welcome to the Huberman Lab podcast, where we discuss science and science-based tools for everyday life.

00:09Recently, the Huberman Lab hosted a live event at the Meridian Theater in Toronto, Ontario.

00:14The event consisted of a lecture entitled The Brain-Body Contract, followed by a question-and-answer session.

00:19We wanted to make sure that the question-and-answer session was available to everybody, regardless of who could attend in person.

00:25I also want to make sure to thank the sponsors of that event, which were AG1 and 8sleep.

00:308sleep makes smart mattress covers with cooling, heating, and sleep tracking capacity.

00:35One of the key things to getting a great night's sleep is to make sure that the temperature

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00:46And in order to wake up feeling refreshed and energized, your body temperature actually

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01:06I've been sleeping on an Eight Sleep mattress cover

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01:21If you'd like to try Eight Sleep,

01:22you can go to eightsleep.com slash Huberman

01:25to save $150 off their pod three cover.

01:28Eight Sleep currently ships to the USA, Canada, UK,

01:31select countries in the EU and Australia.

01:33Again, that's eightsleep.com slash Huberman.

01:35AG1 is an all-in-one vitamin mineral probiotic drink.

01:39I've been taking AG1 since 2012,

01:42so I'm delighted that they sponsored the live event.

01:44The reason I started taking AG1

01:46and the reason I still drink AG1 once or twice a day

01:49is that it provides all of my foundational nutritional needs.

01:52That is, it provides insurance

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02:01physical health, and performance.

02:03If you'd like to try AG1,

02:04you can go to drinkag1.com slash Huberman

02:07to claim a special offer.

02:09They're giving away five free travel packs

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02:14Again, that's drinkag1.com slash Huberman

02:17to claim that special offer.

02:18And now, without further ado, the question and answer session from our live event at the Meridian Theatre in Toronto, Ontario.

02:25Okay, what motivated me to do the guest series with Paul Conti?

02:44Okay, so first of all, for those of you that don't know, Paul Conti is a psychiatrist,

02:47he's a Stanford and Harvard trained psychiatrist, and I wanted to do the series with Paul for

02:53several reasons and we initiated that series. First of all, he's incredibly talented as a clinician

03:01and yet despite having written an excellent book about trauma, I felt that two things were true

03:08for sure. One is that most people won't get the opportunity to work with Paul, sadly. He's time

03:13limited. And second, that his expertise is incredibly vast, not just restricted to trauma.

03:20traumas if understood can be transmuted into you know deep sources of knowledge that other people

03:26can benefit from and indeed what I found in Paul as I got to know him is that he has just profound

03:33insight into the unconscious mind and people had long asked me you know around in and around the

03:39podcast what about the subconscious what about the unconscious and I was of the mind that the

03:45supercomputer of the human brain is the forebrain the thinking planning context setting piece right

03:50right behind our forehead, so it's the reason that we're not the house cats.

03:55The house cats are the house cats, and it's the reason we're the curators of the planet.

03:59But Paul said, oh, no, no, no, no, no, no, no, no, no, no.

04:01The unconscious mind is the supercomputer of the mind.

04:04I'm like, well, that sounds great, but how do we understand the unconscious mind?

04:08And he has a really biological and psychological and psychiatric understanding of the unconscious.

04:13And in that series, he talks about these so-called cupboards that we can look into

04:18in order to better understand our unconscious mind, in order to allow our unconscious mind to

04:23teach us things about ourselves that are useful. And there are three main places where our unconscious

04:30teaches us useful things that allow us to be more conscious of the way that our brain is working in

04:35useful ways. The first is in these liminal states between waking and sleep. It really does seem to

04:43be the case that when surprise surprise we're completely still and we're emerging from or

04:50we're dropping into states of reduced autonomic arousal but our level of thought if you will

04:57is still active enough that we are aware maybe even lucid dreams and also in dreams our unconscious

05:03mind uses as i think jung and freud pretty well understood symbols to teach us things but

05:10But everything's flipped in there.

05:12Gender's flipped.

05:13Like just because you're having a conflict with somebody in your life who's a man

05:18doesn't mean that that person shows up as a man.

05:20They could show up as an animal.

05:21So species are flipped.

05:22The symbols become mishmashed.

05:24But Paul made it very clear that all this can be parsed

05:27if you do a certain kind of introspective work.

05:31And I thought that would mean a lot of talk therapy that people would,

05:33how are we going to get people to learn how to do talk therapy by themselves?

05:36we want to keep things as much independent of cost and things like that. And the practices he

05:43started talking about were incredibly simple. Things like mirror work. Some of the psychologists

05:48in the room will be familiar with this. I thought, mirror work? What is that? And he said, literally,

05:53people trying to activate their unconscious, or excuse me, access their unconscious in sleep by

06:01a practice of staring into the mirror for some period of time while awake and reflecting on

06:06self and aspirations and the idea of the body as a container. All this stuff, even for a kid from

06:12Northern California, sounds really woo new agey. But here it's scripted by Paul into a formal

06:18structure that one can use to parse your own mental health and enhance mental health. So that

06:24was the reason for doing the series. And especially the episode on relationships, not just romantic

06:29relationships I found hasn't come out yet incredibly interesting because he talked about

06:34how in his clinical experience, virtually all the stuff that people pay attention to

06:39in relational stuff is, are they a narcissist? Are they obsessive? Is this person a musician

06:47versus whether or not I'm an accountant? Are we compatible? That none of that stuff predicts

06:52anything as well as the balance of these three drives, the aggressive drive, the pleasure drive,

06:57and the so-called generative drive.

07:00And I found it to be fascinating,

07:02and I'm excited for that episode and the other episodes to come out,

07:04but basically because Paul's brilliant,

07:05and he makes what I consider pretty obscure and opaque

07:10very clear and concrete, and they're a bunch of worksheets,

07:13again, all available at zero cost,

07:15and none of them requiring that you do therapy with anybody

07:18if you choose not to.

07:19This is all the kind of work one could do on oneself.

07:22And the last thing I'll say about this is,

07:25and I should have said this first,

07:26is that the primary motivation was we did a series of Dr. Andy Galpin on physical fitness.

07:31Why isn't there a series on mental fitness?

07:34What is that?

07:35Why do we talk so much about mental health when we're, and it's usually a conversation

07:40about mental illness, what people should have tools and practices that are zero cost, I

07:44believe, to be able to introspect in a structured way and enhance their mental health independent

07:50of their level of income.

07:52And I think Paul was the guy to do it.

07:53And we'll do more of that with other people as well,

07:57because no single episode about any topic or series can exhaustively cover any topic,

08:02although the Lord knows we will try.

08:04Okay, next question.

08:07What are the recommended protocols and best practices to enhance emotional resilience

08:10and develop effective responses during highly triggering situations?

08:13You're asking the wrong guy.

08:17Yeah.

08:19I mean, I don't snap.

08:20I don't snap I was a wild teenager but I don't snap I'm not the aggressor but I do have a snap

08:26button and it's been pushed before and I have to say when that happens it's really kind of a scary

08:33thing not to me right um and it's been many years but I think anyone who's who's hit that threshold

08:39where you just you try not to say something you say it anyway you know that's usually how it shows

08:45up for people. I think we hear the statements like be responsive, not reactive. Okay, that's

08:57why I became a biologist because stuff like that makes no sense to me. In that moment,

09:02how are you responsive, not reactive? So to me, I was like, what are the tools? Clearly,

09:07as you go up that continuum of autonomic arousal, it becomes much harder to do whatever that means,

09:12right so that hence the the tools for reducing stress in real time i think the one that we

09:20haven't emphasized so much on the podcast um and by the way thanks to some great therapy and that

09:27was not voluntary i i was uh able to you know i was a wild kid a wild wild kid hung around wild

09:33kids and um things were pretty different then and we we worked it out you know but i think nowadays

09:40it's wonderful because I think people are more conscious of the need to

09:43understand their nervous system, their own psychology. That wasn't as common back

09:47then. In fact I hid the fact that I had to do therapy for a long time thinking

09:52wow like everyone's gonna think I'm crazy. They did call me crazy. You know I

09:55think things have really changed. I think the last 20 years have brought about a

09:58profound shift in the way that we think about our own species and what what are

10:03useful tools and practices. And I think that one of the things that is abundantly

10:09clear is that that threshold for a stress response really is different for different people,

10:18different in different situations, but that it is something that can be practiced and elevated.

10:23And in terms of not getting near that trigger point through the types of practices I talked

10:30about earlier, getting more comfortable with adrenaline circulating in your system is what

10:34it's really about, frankly. But of course, it all starts with a good night's sleep, right? It's

10:39going to make you far less reactive. But of course, when you're stressed, that's often when you're not

10:44getting good sleep. So I think that ultimately that our ability to, as you know, more emotional

10:52resilience and effective responses during triggering situations is really the consequence

10:57of practices of taking good care outside of those situations. And then of course, inevitably,

11:02there will be situations where people get triggered. And it's actually interesting to see

11:07the way that people behave online and the fact that you know many people in fact in science as

11:12well have literally lost their jobs for having you know not being able to control their thumbs

11:18it's kind of we're in an odd time where there's the the distancing of doing things online as

11:23opposed to in person where people somehow engage in saying things and doing things that they wouldn't

11:29in person but i think that ultimately it's the consequence of good self-care and this gets

11:36actually back to some of the things that are covered in the Conti series. You know, we hear

11:39about self-care as we think that means massages, which are great, by the way, and we think that

11:44that is about exercise, and that's wonderful. But much of self-care is about really making sure that

11:51our nervous system is in the state that we need it to be in in order to go about our day. And I

11:56think this is why morning routines and practices are so vital. I think that those set the stage for

12:01the emotional resilience. They'll set the stage for avoiding getting triggered, so to speak. I don't

12:07think there's a lot that one can do in real time except perhaps physiological sighs. So sorry to

12:13give you a sort of empty answer. I'm not a pessimist on this front, but it's, I think that

12:17ultimately it's like saying, well, what if you have to scale the side of a building to get in,

12:21you locked yourself out, you know, what can you do to prepare for that? Well, you can buy a ladder,

12:25but if you don't have a ladder, you know, what, because what you probably should do is be physically

12:31fit enough to you know climb up a railing or something like that and know how to pick a lock

12:34or something like that. So I think ultimately that it's the consequence of stuff that's done

12:39away from those triggering situations. Next question please. How would you describe the

12:47brain activity of somebody when they're suddenly inspired and hadn't fostered inspiration in

12:51your life? Well I talked a little bit about this but I will say that the best way to foster

12:56inspiration is in the words of the great Joe Strummer. They actually call it Strummer's Law,

13:02no joke. No input, no output. I think one of the things that I've observed over and over again is

13:09that as much as we need to dedicate ourselves to our craft, to our families, to our friends,

13:14that ultimately our best ideas come from disparate experiences when we're not seeking

13:22a particular kind of input to get ideas. Now maybe this practice of being completely still

13:28while being alert fosters a lot of, I think the way I understand it is more of a geysering up

13:35of stored information in the unconscious. That's how I think Rick would talk about it or Paul

13:42Conti would talk about it as geysering up from the unconscious because when we are focused on

13:47the outside world we're taking in sensory information, exteroception as

13:52opposed to interoception. And of course that external info, sensory information

14:00that no input no output is that those are the raw materials that our nervous

14:04system uses to construct ideas about anything. So my belief, and this is a

14:10practice I do every week, is I make sure that at least once a week I either walk

14:14or hike or run without any earphones and I'm trying to get into states of wordlessness states

14:20where I'm not digesting a podcast where I'm not reading a book where I'm not listening to a lecture

14:25where I'm not in conversation and essentially trying to turn off that the linguistic narrative

14:33we are a storytelling species we tend to take all all of our internal and external experience

§02Transcript — part 2

14:39and construct things around language, but spoken language is not the language of the nervous system.

14:47The language of the nervous system still remains to be identified. It's something else. For people

14:51that think and feel, it will certainly incorporate that. Spoken language, of course, is important,

14:57and we have some core structures to spoken language. We covered this in the podcast episode

15:01with my friend Eddie Chang. But ultimately the the way to come up with new ideas of inspiration is

15:10going to be to collect the raw materials of experience and then give ourselves these periods,

15:16maybe even just five, ten minutes, you have to lay around half the day doing nothing still wide

15:20awake and give that those raw materials the opportunity to to marinate and combine in whatever

15:27ways that are unique to you and then to geyser up. What inspiration looks like in the brain,

15:33we don't really know. There's awe. There's some studies about awe, but that's different.

15:39The word that better comes to mind is delight. Awe, in my mind, is something that we witness

15:46that sort of overwhelms our attention. Like, wow. Delight is when it somehow links up with

15:54our own internal narrative. Like, I have something to do with what's happening. I'm not just here to

15:59witness it. You know, a firework show, a really impressive firework show, is like, aw. But there's

16:05nothing to do about it. It doesn't relate to anything about you, really. You're purely a

16:11spectator. Whereas delight is when you see something and it somehow links to something in

16:15your emotional or personal history or how you're wired, that now there's something to do about it.

16:21That's inspiration.

16:23And we don't understand where that exists in the brain or what that looks like.

16:27But I think we all recognize that feeling when it happens, and it's oh so wonderful.

16:34Okay, next question, please.

16:36How can Canadians fight the seasonal depression winters are too long here?

16:41Okay.

16:41Okay, well, this gives me an opportunity to share with you what I think is one of the coolest things about our species.

16:51Notice I say that about many things.

16:55So we've talked about circadian rhythms, right?

16:57Sunrises, sunsets.

16:59And we get that information transmitted into our nervous system by looking at the sunrise.

17:04By the way, you don't have to watch the sun cross the horizon.

17:07It just needs to be low solar angle, low in the sky.

17:11Once it's overhead, it's a different signal.

17:13So low solar angle, that's what it's about.

17:15It's not necessarily about seeing the sun cross the horizon.

17:17it. By the way, someone the other day on my team said, wait, won't you get cataracts if you look

17:23at the sun? Low solar angle sunlight is very unlikely to cause cataracts, especially if you're

17:27just doing it 10 to 30 minutes. That solar, you know, the sun overhead is when it's quite bright.

17:33Yes, indeed, some people are going to be at risk for cataracts. So ophthalmologists in the audience

17:38can attack me for that one. But it was our chair of ophthalmology at Stanford that said it, so I'm

17:41to trust him. Okay. That's circadian 24-hour rhythms, but there's also these circannual rhythms.

17:50So if you're at a fairly northern location on the planet, nights get very long, days get short in

17:57winter. What happens then? Well, melatonin, the hormone of darkness, right, is essentially

18:04obliterated by light, by sunlight. So what's happening when days are, you know, 12 hours long,

18:11you have very little melatonin, the duration of the melatonin signal is very short.

18:17Then as you proceed into the fall, days are getting shorter, nights are getting longer,

18:20the duration of the melatonin signal is getting longer and longer.

18:24Then, of course, in winter, there's a lot more darkness.

18:28Melatonin signals are very long.

18:31Daylight signals are very short because the days are short.

18:34So you could say, okay, well, that's obvious, thank goodness.

18:38but what that means is incredible. What that means is that you have a hormone, melatonin,

18:45that's secreted from your pineal gland, which Descartes called the seat of the soul

18:49because there's only one of them in the brain. I don't know how he came up with that one, but

18:56the pineal secretes melatonin and you suppress melatonin secretion with sunlight viewing.

19:03There's a couple of synapses in between the eye and the pineal, but it gets there,

19:06up through the neck, basically, a cervical ganglia. What's wild, therefore, is that the location of the

19:14earth around the sun and the tilt of the earth is translated into a neural and then a hormonal

19:21signal in your brain, which to me is amazing. That literally means that the position of the earth

19:28around the sun and its tilt are translated into a physiological signal that's working

19:34unconsciously to tell your brain and body what time of year it is, but it doesn't care what time

19:39of year it is. It cares about where you are in this orbit about the sun. So if you think about

19:48when days are, say, eight hours long in the fall versus eight hours long in the spring, what's

19:55different? What's different is how long the signal was the day before. So the seasonal depression we

20:02now know is the consequence of the melatonin signal getting longer, not an absolute duration

20:08of the melatonin signal. In other words, in the spring when a day is eight hours long,

20:15but yesterday the day was seven hours and 48 minutes long, your brain has a memory of how

20:23much melatonin was released the day before, much more, than that particular day. So it's a slow

20:30integrating clock. So this is a very roundabout way for me to teach you about the melatonin

20:35seasonal rhythm cycle and answer the question directly by saying, if you want to offset seasonal

20:41depression, what you want to do is extend the amount of bright light that you're getting in

20:46the morning slightly as days get shorter. But it's the extension of the bright light exposure.

20:51And if you can't do that with sunlight, because there's no sunlight because you live in Toronto,

20:54not Toronto, what you want to do is find some artificial source that you can look at in the

21:01morning before you leave your home. And I haven't talked much about this on the podcast because our

21:06listeners are extended around the globe and not just in northern locations. But what this

21:13essentially means is getting maybe two to three minutes of bright light exposure as you're heading

21:18from fall into winter. Bright light from an artificial source. You do not need to purchase

21:22a so-called sad lamp one of these very expensive seasonal affect depression lamps you can what I

21:29did was I purchased because I'm very sensitive to seasonal changes in light even though I don't live

21:33very far north is you can get a 900 lux drawing tablet these are quite inexpensive they're not

21:39zero cost but quite inexpensive and just put that on your desk or on your wherever you make your

21:46coffee in the morning 90 minutes after you wake up this sort of thing and just get five or so

21:51minutes before you leave the house. And then as you extend into the winter, you don't have to be

21:56neurotic about increasing the duration every day. You could actually, the way these slow integrating

22:02clocks work, you could actually even just hold it a little bit closer each day. Don't burn your

22:06eyeballs out a little bit closer each day. But essentially, if you just dose yourself with a

22:10little bit more bright light early in the day as you extend into winter, that will essentially trick

22:16the melatonin system into thinking that you're going from eight hours into 10 hours of light,

22:23as opposed to eight hours into six hours of light. Okay. Very simple. And if you can't get

22:29one of these 900 lux tablets or something off a website, then you could do this with any bright

22:34incandescent bulb should work. Again, just be careful not to put it directly against your eyeball.

22:41okay next question please how do you increase neuroplasticity well this this is an opportunity

22:47to talk about something i should have said earlier which is that ultimately whether or not you are

22:52triggering neuroplasticity through elevated focus or whether or not you're taking high dose psilocybin

22:57your business not mine um and we could talk about psychedelics if you want um just decriminalized in

23:04california or soon to be decriminalized cool people are enthusiastic yeah the one thing i've

23:10I've been pretty vocal about my belief that the data are really interesting, to say the

23:16least, about not microdosing.

23:19By the way, there's not a lot of evidence that microdosing is useful.

23:22I'm not saying it's not, but there are not a lot of clinical trials showing that.

23:26But the two macrodose with effective therapeutic support trials are very encouraging, not just

23:34for major depression, but also for various eating disorders, alcohol use disorder, which

23:39which is by the way that the term that people are starting to shift to as opposed to alcoholism

23:43or alcoholic alcohol use disorder, which is not to be politically correct, but just so

23:50you understand what they're talking about when they're talking about alcohol use disorder.

23:56Whether or not psilocybin, whether or not it's MDMA, whether or not it's frustration

23:59brought about by your inability to play an instrument and you know your determination

24:04to do so, it's in the end it's all about deployment of these neuromodulators.

24:09neuromodulators being some combination of dopamine, serotonin, acetylcholine, or epinephrine,

24:17again, usually in combination. What's very clear is that the neuroplastic effects of MDMA,

24:22the neuroplastic effects of psilocybin are brought about by huge increases in serotonin.

24:27This also can help us understand why for some years, and to some extent still now, it was thought

24:34that the SSRIs, the selective serotonin reuptake inhibitors, would be good treatments for depression.

24:39I think some people, by the way, have experienced tremendous relief from the SSRIs.

24:43We don't want to demonize them.

24:45At the same time, it's very clear that depression is not simply low levels of serotonin.

24:51That's also not true.

24:53Hence why there's effective, in some people, antidepressants like bupropion

24:59that increase dopamine and epinephrine and not serotonin.

25:04The point here is that these neuromodulators, as they're called, allow for what?

25:09They allow for modulation of synapses, which effectively allows for neuroplasticity.

25:15I mean, ultimately, whether or not it's through talk therapy, kundalini breathing,

25:20high-dose psilocybin, MDMA, or the combination, which I think is called a hippie flip.

25:27Never done them together.

25:29I confess, never done them together, but have done them.

25:36With a clinician, by the way, in legal circumstances, and not a lot, not often, that is,

25:44it's very clear that it's opening windows for plasticity.

25:47Now, what's intriguing, if we're going to just talk about psychedelics for a second,

25:51is why a drug like MDMA, which increases dopamine, which, by the way, MDMA is methylene-dioxymethamphetamine.

25:57don't let anybody tell you it's something there it's meth it's meth but it's meth with a lot of

26:04serotonin thrown in there too but it's meth and it's clear that for the treatment of ptsd it holds

26:11promise it's not absolutely safe especially for people with cardiac conditions and you if you're

26:17going to go down that path you want and need a skilled guide and this is where i think the laws

26:22are really going to have to pay careful attention to what who and what is a skilled guide okay

26:27And when it comes to psilocybin, the serotonin increase is what effectively causes broader

26:36connectivity in the brain.

26:37And what's interesting is that both of those drugs increase plasticity mainly through increases

26:41in serotonin, but working on very different receptors.

26:44So they have different types and outputs of plasticity.

26:47What's interesting to me is that because I'm a strong believer that children should not

26:51be doing psychedelics, nor should we be giving children psychedelics, is that the increases

26:56in connectivity in the brain that are the consequence of playing a musical instrument

27:01or ideally an instrument with others as a child mimic a lot of the broader scale connectivity

27:08sort of called so-called resting network connectivity that occurs when people take

27:13psychedelics as adults in other words and i can't emphasize this enough and again i failed at music

27:18miserably i'll tell you a story about that in a second but so getting kids to play an instrument

27:24is it's very clear improves their ability to learn all sorts of things for their entire life.

27:31It's just so, so important. I don't really know what to do about this or who to shout at or talk

27:36to about keeping the arts active in schools and physical education, but the idea that we would

27:42just train kids in math is just frightening because if you want them to be truly good at

27:47math and science, you'd also have them play instruments. By the way, when I was a kid,

27:50I played the violin. My parents made me. It was not the instrumental I wanted to play.

27:55And we have only one picture. And they taught me the Suzuki method.

27:59You're supposed to learn by ear. And there's one picture.

28:01And all the other kids have their bows up. And my bow is down.

28:05And I'm standing here on the stage. And my fly is down.

28:10And that and literally the neighbor's dog howled. And I quit after that concert.

28:15So I was traumatized by it. They showed me the picture. My sister teased me relentlessly.

28:20So neuroplasticity, figure out your choice way to increase a neuromodulator like serotonin or epinephrine, acetylcholine or dopamine.

28:30I honestly would not encourage pharmacologic or psychedelic approaches as your primary entry point.

28:37I really don't.

28:38I think that there's a place for that in certain circumstances, but that would not be the primary entry point.

28:44Next question, please.

28:45what type of movement protocol do you recommend for somebody who's working from home sitting

28:50behind the computer from 8 a.m to 5 p.m oh um okay well a couple things i mean i can make all sorts

28:59of recommendations like get up early and you know move and if you can take breaks and walk this sort

29:04of thing but let's let's assume that all of that is is kind of understood that there are certain

29:09forms of exercise that we should all be doing three i think now it's very clear based on the

29:13beautiful work of Peter Attia, whose brother is in the audience, by the way, tonight. Yeah, yeah.

29:19He's got a younger brother. He's got a younger brother. Can you imagine if Peter Attia was your

29:23older brother? Can you imagine? That'd be pretty cool. I sort of adopt people as siblings because

29:30they don't know it, but I do. But I just assume Peter was my older brother, but turns out he has

29:34a younger brother already. And Peter's essentially hammered home the truth, which is that we should

29:39all be getting somewhere between 150 to 200 minutes of so-called zone 2 cardio where we're

29:44walking a lot and we're moving about where we can just barely hold a conversation. I notice people

29:49in Toronto seem to walk a lot so that's great. And then three days a week or so resistance training

29:56and there are a bunch of other mobility things that we should all do so that we don't fall and

29:59break our hips because that's where another bone because that's another way that people really

30:03limit their healthspan and lifespan and so on and so forth. But two things that can make

30:08being at a desk, which I loathe, even though I like to learn, I hate sitting still.

30:13You can do the standing desk thing. I do that by stacking boxes. The other thing that was

30:17interesting, did anyone see this study out of the University of Texas? I think it was in Houston

30:21this last year about the soleus push-up. Did anyone see this? This is pretty interesting.

30:27So the soleus, this wider flat muscle below the gastrocnemius of the calf, is a really unique

30:33muscle in the human body. It's 1% of the total human musculature, but it has an ability

30:37what will soon be for obvious reasons to dramatically shift fuel utilization in the

30:46body what they did in this study was they had people who were sitting for you know three or

30:50four hours a day just simply raise their heel seems almost silly right they call it a soleus

30:54push-up when I called it that online I literally got attacked by the gym bros telling me that's a

31:00seated calf raise. Okay. You know, I mean, like, okay. No wonder they, you know, this whole

31:07broscience thing gets kind of, you know, people get really aggressive. They lift their heel and

31:14they put, they're pushing their toe down. And some people think of it as bouncing the knee,

31:17but it's really about pushing the toe down and lifting the heel. So they just simply had these

31:20sedentary people do this heel raise. And what they saw was that there was a dramatic,

31:26highly statistically significant increase in blood glucose utilization and reduction in both

31:33insulin levels during that activity and around the clock. Really interesting. What they were

31:39doing was mimicking some aspect of walking. Now, is it as good as walking? No. But if you are stuck

31:46behind a, you know, working from home, sitting behind the computer from 8 a.m. to 5 p.m.,

31:51what they found was that people getting into this unconscious pattern of lifting their heel over and

31:56over and shifting back and forth mimics a lot of the effects of walking it's not a replacement for

32:00exercise but the shifts in glucose and insulin output and utilization excuse me utilization and

§03Transcript — part 3

32:07output respectively were very impressive and this group down at the University of Houston

32:12University of Texas in Houston is starting to incorporate this into people who have limited

32:17mobility and it doesn't seem like other limb movements can do this there's something special

32:23about the soleus it was designed in air quotes to be a muscle that's used repeatedly over you know

32:31extended hours of time and that has this unique pathway of fuel utilization so is it going to cure

32:36obesity no but if you're stuck behind a desk that would be something useful I have this little fidget

32:41thing I was too lazy to build one but I found one online for a couple bucks where you just when you

32:46stand at your desk and just you kind of kick it back and forth everyone seen these these are kind

32:50cool then you just kind of kick them back and forth and some people will treadmill at the desk

32:54i can't do that i can't do that many things but i also i'm still like working on this one

32:58i can't quite do that uh next question please my morning meditation consists of okay and then i

33:04think we're about out of time but the um yeah so my morning meditation is not really a meditation

33:10it's a perceptual exercise and um that perceptual exercise is has a weird name because i gave it a

33:18weird name. And I didn't intend to sound mystical and I don't want credit for it, but I call it

33:25space-time bridging, but it's not that. What it really is, is that the, to me, one of the most

33:30interesting things about the nervous system is our ability to orient in different time domains.

33:35This gets a little bit abstract, but we know from states of high stress that we start fine slicing

33:40time. We know this, right? The world becomes like a slow motion video because frame rate has

33:45increased. As a vision neuroscientist, I can tell you that in my laboratory, we were doing studies

33:50with virtual reality where we can crank up people's level of stress by giving them certain

33:54visual stimuli. And then their ability to parse information is clearly increasing in the time

34:00domain. They're fine slicing much in the same way that when you look at a slow motion video,

34:04somebody dunking a basketball or something of that sort is because the frame rate went up,

34:08right? So when we are in high alertness states, our frame rate increases. When we're very relaxed,

34:14our frame rate decreases. So if you're Rick Rubin and you're lying there looking at the sky,

34:20your frame rate is probably slower than if you're hyper-focused on, oh my goodness, you know,

34:25like you said, like imagine a dreadful situation where somebody sends you a text message. Well,

34:30let's make it positive. Somebody's having a child in your family and you're like,

34:34you know, is it a healthy, yeah, are mom and baby okay? I mean, seconds feel like minutes,

34:42minutes feel like hours because you're fine slicing time okay and then mom and baby you're

34:46fine okay great happy story ending great so when we're very relaxed we tend to bin time more broadly

34:53now it's also true that your visual system and your perception of time are inextricably linked

34:59such that if you close your eyes and you focused on your internal state

35:03you are fine slicing time and the second hand if you will is more or less the metronome

35:11rather is your breathing and your heart rate combined. When you open your eyes and

35:17you look at something in your immediate environment, when you move from so-called interoception to

35:22exteroception, you start your perception of time shifts fairly dramatically and you now perceive

35:30time according to believe or not the speed of images moving in your environment relative to you

35:34and then as you look out further on to say the horizon you extend the time domain even more

35:39If you then imagine yourself kind of in the whole globe, you extend your time domain even more.

35:46So my morning meditation, if you will, it's more of a perceptual exercise, is to step through these different time domains to close my eyes and focus on my internal state.

35:56Open my eyes and focus on something close by.

35:59Look a little bit further, look a bit further.

36:01Think about myself on the globe, the whole world moving.

36:06so you're really extending your space domain and then the time domain expands with it. You know,

36:12and this comes up when you see these little memes of, you know, anytime you're worried,

36:15just remember you're a little dot on a little blue dot spinning in the universe, you know,

36:19this kind of thing. But you don't think that way when you're stressed. You're thinking,

36:22I'm the blue dot. You're the problem, whatever, you know, I want that. You know, you're not

36:27thinking. So this perceptual exercise is a way of training the nervous system,

36:32my nervous system to shift deliberately between these different time domains. And for me,

36:36it's been very useful for improving task switching, something that as you probably have noticed,

36:42I'm not very good at. I go into the trench, I don't leave the trench very easily. So that's

36:48been very useful. And if you are interested in this in more detail, there's a wonderful book

36:53called The Secret Pulse of Time. And there's a Hitchcock movie that's discussed in that book,

37:01which the movie is about 75 minutes long and during the course of that movie the background

37:07actually includes rising and setting of the sun and a bunch of different speeds of movement and

37:11interplay between the characters and your perception at the end of the movie is that a much

37:16much longer period of time occurred because of unconsciously your brain was paying attention to

37:24these circadian signals and these other signals and absolutely fascinating and hitchcock not a

37:28huge Hitchcock fan but now I after seeing that I was like wow that's genius he captured this space

37:33time thing what you see out the window is in one time domain in the room is a different time domain

37:38I won't tell you who killed who but it's very very interesting and so the point being that when your

37:44visual system is up close focusing on things up close or internally you're you're fine slicing

37:49when you focus on things further away you're more broadly focusing and so on and so forth so that's

37:55morning meditation i do it only perceptual exercise only takes about a minute or so

37:59and the other thing is that on the monitors they're flashing now that was your last question so i i

38:05want to just say a couple of things before we go first of all thanks to all of you who um stood

38:10out the night for the long duration i realize this stuff is like nerdy detailed and there are a lot

38:14of other things you could be doing with your evening and your time and so i'm very grateful

38:20that came together tonight for this, what I like to think was a discussion.

38:25And I also just want to thank everyone for your interest in the podcast.

38:29You know, it is a labor of love.

38:32I'm highly dependent on my team for doing all of it.

38:34I don't do it alone by any stretch.

38:36But as much as it might seem like it's me talking to all of you,

38:39it really is about all of you.

38:42That's the reason I do it.

38:43And I'm ever so grateful.

38:45And I'd certainly be remiss if I didn't say thank you for your interest in science.

38:52Thank you.

38:57Thank you.

— A LITTLE MORE TO THINK ABOUT. —